And the answer is: Former doctor turned billionaire, Leonard Schleifer, who is the CEO of biotech powerhouse, Regeneron.
In 2011 the company created a treatment that restored vision in older adults. From June of 2011 to June of 2014, Regeneron stockholders saw a 398% return on their investments - the biggest in the S&P.
The company has been around for 25 years, so it wasn't an overnight success, but if you bought shares for $30 in 2011, you're more than ecstatic to see them trading for more than $330 today.
See who rounds out the top 5 here.